Potential side effects experienced with bisphosphonates include heartburn and various digestive problems, allergic reactions, esophageal ulcer, esophageal cancer, difficulty swallowing, headaches, joint muscle pain or cramps, fever flu-like symptoms, serious atrial fibrillation, and osteonecrosis of the jaw. This is a condition in which the bone tissue in the jaw fails to heal after minor trauma such as a tooth extraction, causing the bone to be exposed... Full Text